The TPX2 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to TPX2, and TPX2 microtubule nucleation factor. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The TPX2 antibody has been validated for the following applications: EIA, Immunoassay, Precipitation, ELISA, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation(PubMed:26165940)